| 1. Gang Wang, Qian Li , Sumei Liu, Mo Li, Baoguo Liu, Tianyao Zhao, Bochao Liu** , Zhiguo Chen*.An injectable decellularized extracellular matrix hydrogel with cortical neuron-derived exosomes enhances tissue repair following traumatic spinal cord injury. .2024.14-28. .SCI(含SCIE) |
| 2. Zhongfeng Liu, Weihua Liu, Zhiguo Chen*, Hua Kang ,**.In vitro differentiation of human CD45+ CD34+ induced hematopoietic progenitor cells from iPSCs using a monolayer system. .2024.63-1. .SCI(含SCIE) |
| 3. Qian Li, Sumei Liu, Tianqi Zheng, Mo Li, Boling Qi, Liping Zhou, Bochao Liu, Dan Ma, Chao Zhao，Zhiguo Chen*.Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury. .2024.15-1. .SCI(含SCIE) |
| 4. Sumei Liu, Baoguo Liu, Qian Li, Tianqi Zheng, Bochao Liu, Mo Li, Zhiguo Chen*.Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment. .2024.19-2. .SCI(含SCIE) |
| 5. Mo Li, Xinyu Wang, Boling Qi, Shengyu Cui, Tianqi Zheng, Yunqian Guan, Longbing Ma, Sumei Liu, Qian Li, Zhiguo Chen, Fengzeng Jian .Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells. .2024.21-4. .SCI(含SCIE) |
| 6. Mo Li, Boling Qi, Qian Li, Tianqi Zheng,Ying Wang, Bochao Liu, Yunqian Guan, Fengzeng Jian, Zhi-qing David Xu, Qunyuan Xu, Zhiguo Chen*.Human induced pluripotent stem cell/embryonic stem cell-derived pyramidal neuronal precursors show safety and efficacy in a rat spinal cord injury model. .2024.81-1. .SCI(含SCIE) |
| 7. Xueyao Wang, Deqiang Han*, Tianqi Zheng, Jinghong Ma, Zhiguo Chen*.Modulation of human induced neural stem cell-derived dopaminergic neurons by DREADD reveals therapeutic effects on a mouse model of Parkinson’s disease. .2024.15-1. .SCI(含SCIE) |
| 8. Li X#, Guan Y#, Chen D, Li J, Yu W, Zou H, Liu B, Chen L, Chen Z*.Immune Cells Promote BDNF Expression by Infiltrated Macrophages via Interleukin 4 in the Cerebral Ischemia of Male Rats.. .2024.102-9. .SCI(含SCIE) |
| 9. Xin Zheng#, Deqiang Han#, Weihua Liu, Xueyao Wang, Na Pan, Yuping Wang, Zhiguo Chen*.Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease. .2023.Vol.13(8): 2673-2692. . |
| 10. Wang L#, Wang X#, Chen Q, Wei Z, Xu X, Han D, Zhang Y, Chen Z*, Liang Q*.MicroRNAs of extracellular vesicles derived from mesenchymal stromal cells alleviate inflammation in dry eye disease by targeting the IRAK1/TAB2/NF-κB pathway. .2023.Vol.28. . |
| 11. Zhang Q#, Chen Z, Zhang K, Zhu J, Jin T*.FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis. .2023.Vol.29(6). . |
| 12. Zhiguo Chen#*, Guoguang Zhao.First-in-human transplantation of autologous induced neural stem cell-derived dopaminergic precursors to treat Parkinson’s disease. .2023.Vol.68(22). .SCI(含SCIE) |
| 13. Liu S, Ma L, Qi B, Li Q, Chen Z*, Jian F*.Suppression of TGFβR-Smad3 pathway alleviates the syrinx induced by syringomyelia. .2023.Vol.13(1):98. . |
| 14. Weihua Liu#, Yu Zhao#, Zhongfeng Liu, Guangji Zhang, Huantong Wu, Xin Zheng, Xihe Tang, Zhiguo Chen*.Therapeutic effects against high-grade glioblastoma mediated by engineered induced neural stem cells combined with GD2-specific CAR-NK. .2023.Vol.46（-）. . |
| 15. Zhang G, Zhao Y, Liu Z, Liu W, Wu H, Wang X, Chen Z*.GD2 CAR-T cells in combination with Nivolumab exhibit enhanced antitumor efficacy. .2023.Vol.32. . |
| 16. Huantong Wu, Yajie Yu, Yu Zhao, Weihua Liu, Zhongfeng Liu, Guangji Zhang, Zhiguo Chen*.A CH2CH3 hinge region enhances the cytotoxicity of anti-CD5 CAR-T cells targeting T cell acute lymphoblastic leukemia. .2023.124 (2023)110904. .SCI(含SCIE) |
| 17. Yingli Jing#, Degang Yang, Fan Bai, Qiuying Wang, Chao Zhang, Yitong Yan, Zihan Li, Yan Li, Zhiguo Chen*, Jianjun Li*，Yan Yu*.Spinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids. .2023.9-1. . |
| 18. Zhou L#, Han D, Wang X, Chen Z*.Probiotic Formulation VSL#3 Interacts with Mesenchymal Stromal Cells To Protect Dopaminergic Neurons via Centrally and Peripherally Suppressing NOD-Like Receptor Protein 3 Inflammasome-Mediated Inflammation in Parkinson's Disease Mice. .2023.Vol.11(2):e0320822. . |
| 19. Liu B#, Li M#, Zhang L*, Chen Z*, Lu P*..Motor neuron replacement therapy for amyotrophic lateral sclerosis.. .2022.17(8). . |
| 20. Jing Y, Bai F, Wang L, Yang D, Yan Y, Wang Q, Zhu Y, Yu Y*, Chen Z*..Fecal Microbiota Transplantation Exerts Neuroprotective Effects in a Mouse Spinal Cord Injury Model by Modulating the Microenvironment at the Lesion Site.. .2022.25. . |
| 21. Liping Zhou, Xingzhe Wang, Xueyao Wang, Jing An, Xin Zheng, Deqiang Han, Zhiguo Chen*..Neuroprotective effects of human umbilical cord mesenchymal stromal cells in PD mice via centrally and peripherally suppressing NLRP3 inflammasome-mediated inflammatory responses.. .2022.153. . |
| 22. Yu Zhao, Jianping Zhang, Junfang Yang, Huantong, Yao Chen, Nannan Li, Zhongfeng Liu, Xuan Wang, Weihua Liu, Guangji Zhang, Bin-Bing Stephen Zhou*, Peihua Lu*, Zhiguo Chen*.Long-Term Safety and Effificacy of CD19 Humanized Selective CAR-T Therapy in B-ALL Patients Who Have Previously Received Murine-Based CD19 CAR-T Therapy. .2022.12. . |
| 23. Fengyan Li, Aixia Zhang, Mo Li, Xueyao Wang, Xuan Wang, Yunqian Guan, Jing An, Deqiang Han, Y. Alex Zhang*, Zhiguo Chen*..Induced neural stem cells from Macaca fascicularis show potential of dopaminergic neuron specification and efficacy in a mouse Parkinson’s disease model.. .2022.124(6). . |
| 24. . Mengjia Li, Zhengbo Wang, Tianqi Zheng, Tianzhuang Huang, Baoguo Liu, Deqiang Han, Sumei Liu, Bochao Liu, Mo Li, Wei Si, Y. Alex Zhang*, Yuyu Niu*, Zhiguo Chen*..Characterization of human induced neural stem cells and derivatives following transplantation into the central nervous system of a nonhuman primate and rats.. .2022.2022. . |
| 25. Yingli Jing; Yan Yu; Fan Bai; Limiao Wang; Degang Yang; Chao Zhang; Chuan Qin; Mingliang Yang; Dong Zhang; Yanbing Zhu; Jianjun Li*; Zhiguo Chen*..Effect of fecal microbiota transplantation on neurological restoration in a spinal cord injury mouse model: involvement of brain-gut axis. .2021.9（59）. . |
| 26. Guan Y#, Wang R#, Li X, Zou H, Yu W, Liang Z, Li L, Chen L, Zhou L*, Chen Z*..Astrocytes constitute the major TNF-α-producing cell population in the infarct cortex in dMCAO rats receiving intravenous MSC infusion.. .2021.142. . |
| 27. Deqiang Han , Wei Zheng , Xueyao Wang and Zhiguo Chen*.Proteostasis of α-Synuclein and Its Role in the Pathogenesis of Parkinson’s Disease.. .2020.14(45). . |
| 28. Kai Wang, Yu Zhao, Xuan Wang, Bin Wang, Maoquan Qin, Guanghua Zhu, Huantong Wu, Zhongfeng Liu, Xueling Zheng, Huyong Zheng*, Zhiguo Chen*..Humanized selective CD19CAR-T treatment induces MRD-negative remission in a pediatric B-ALL patient with primary resistance to murine-based CD19CAR-T therapy.. .2020.Vol.11:581116. . |
| 29. Han D, Zheng X, Wang X, Jin T, Cui L, Chen Z*.Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases.. .2020.2020:8838046. . |
| 30. Li X#, Yu W#, Guan Y#, Zou H, Liang Z, Huang M, Zhao R, Zhao C, Ren Z, Chen Z*.Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model.. .2020.2020:8853444. . |
| 31. Kai Wang, Yu Zhao, Xuan Wang, Bin Wang, Maoquan Qin, Guanghua Zhu, Huantong Wu, Zhongfeng Liu, Xueling Zheng, Huyong Zheng*, Zhiguo Chen*..Humanized selective CD19CAR-T treatment induces MRD-negative remission in a pediatric B-ALL patient with primary resistance to murine-based CD19CAR-T therapy. .2020.11. . |
| 32. Han D, Zheng X, Wang X, Jin T, Cui L, Chen Z*..Mesenchymal Stem/Stromal Cell-Mediated Mitochondrial Transfer and the Therapeutic Potential in Treatment of Neurological Diseases.. .2020.2020. . |
| 33. Li X#, Yu W#, Guan Y#, Zou H, Liang Z, Huang M, Zhao R, Zhao C, Ren Z, Chen Z*..Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model. .2020.2020. . |
| 34. Lei L, Chen H, Lu Y, Zhu W, Ouyang Y, Duo J, Chen Z*, Da Y*.Unusual electrophysiological findings in a Chinese ALS 4 family with SETX-L389S mutation: a three-year follow-up.. .2020.268. . |
| 35. Yu Zhao#, Zhongfeng Liu#, Xuan Wang#, Huantong Wu, Jianping Zhang, Junfang Yang, Fayou Zhang, Lining Liu, Jiafu Long, Peihua Lu, and Zhiguo Chen*.Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies. .2019.Vol.25(18). . |
| 36. Heng Chi , Yunqian Guan , Fengyan Li , and Zhiguo Chen*.The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinson’s Disease Model.. .2019.28(1S). . |
| 37. Zheng W, Chen Z*.Generation of induced neural stem cells from peripheral mononuclear cells and differentiation toward DA neuron precursors for transplantation studies.. .2019.(149). . |
| 38. Zhongfeng Liu, Xuan Wang, Kewen Jiang, Y. Alex Zhang*, Zhiguo Chen*.TNF-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells. .2019.10-6. . |
| 39. Zhongfeng Liu, Xuan Wang, Kewen Jiang, Y. Alex Zhang*, Zhiguo Chen*.TNF-induced Up-regulation of Ascl2 Affects the Differentiation and Proliferation of Neural Stem Cells.. .2019.10(6). . |
| 40. Heng Chi , Yunqian Guan , Fengyan Li , and Zhiguo Chen*.The Effect of Human Umbilical Cord Mesenchymal Stromal Cells in Protection of Dopaminergic Neurons from Apoptosis by Reducing Oxidative Stress in the Early Stage of a 6-OHDA-Induced Parkinson’s Disease Model.. .2019.28(1S). . |
| 41. Liu S, Chen Z*.Employing endogenous NSCs to promote recovery of spinal cord injury.. .2019.2019. . |
| 42. Zheng W, Chen Z*..Generation of induced neural stem cells from peripheral mononuclear cells and differentiation toward DA neuron precursors for transplantation studies.. .2019.149. . |
| 43. Li M, Wang Y, Zhang J, Cao Z, Wang S, Zheng W, Li Q, Zheng T, Wang X, Xu Q, Chen Z*..Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials.. .2018.29（17）. . |
| 44. Yanpeng Yuan, Xihe Tang, Yun-Fei Bai, Shuyan Wang, Jing An, Yanchuan Wu, Zhi-Qing David Xu,Y. Alex Zhang*,Zhiguo Chen*..Dopaminergic neurons differentiated from human blood-derived induced neural stem cells show efficacy in a mouse Parkinson’s disease model.. .2018.8(17). . |
| 45. Yunqian Guan#, Xiaobo Li#, Wenxiu Yu#, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen*..Intravenous transplantation of mesenchymal stem cells reduces the number of infiltrated Ly6C+ cells but enhances the proportions positive for BDNF, TNF-1and IL-1 in the infarct cortices of dMCAO rats.. .2018.2018. . |
| 46. Li M, Wang Y, Zhang J, Cao Z, Wang S, Zheng W, Li Q, Zheng T, Wang X, Xu Q, Chen Z*..Culture of pyramidal neural precursors, neural stem cells, and fibroblasts on various biomaterials.. .2018.29(17). . |
| 47. Wei Zheng, Qian Li, Chao Zhao, Yuwei Da, Hong-Liang Zhang*, Zhiguo Chen*.Differentiation of Glial Cells from hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy.. .2018.12. . |
| 48. Yunqian Guan#, Xiaobo Li#, Wenxiu Yu#, Zhaohui Liang, Min Huang, Renchao Zhao, Chunsong Zhao, Yao Liu, Haiqiang Zou, Yanli Hao, Zhiguo Chen*..Intravenous transplantation of mesenchymal stem cells reduces the number of infiltrated Ly6C+ cells but enhances the proportions positive for BDNF, TNF-1 and IL-1 in the infarct cortices of dMCAO rats.. .2018.2018. . |
| 49. Yanpeng Yuan, Xihe Tang, Yun-Fei Bai, Shuyan Wang, Jing An, Yanchuan Wu, Zhi-Qing David Xu, Y. Alex Zhang*, Zhiguo Chen*..Dopaminergic neurons differentiated from human blood-derived induced neural stem cells show efficacy in a mouse Parkinson’s disease model.. .2018.8(17). . |
| 50. Shuyan Wang#, Zhongfeng Liu#, Yanxia Ye#, Bingnan Li, Tiantian Liu, Weiqi Zhang, Guang-Hui Liu, Y. Alex Zhang, Jing Qu*, Dawei Xu*, Zhiguo Chen*..Ectopic hTERT expression facilitates reprograming of fibroblasts derived from patients with Werner syndrome as a WS cellular model.. .2018.9(9). . |
| 51. Wei Zheng, Qian Li, Chao Zhao, Yuwei Da, Hong-Liang Zhang*, Zhiguo Chen*..Differentiation of Glial Cells from hiPSCs: Potential Applications in Neurological Diseases and Cell Replacement Therapy.. .2018.12. . |
| 52. Li P#, Li M#, Tang X, Wang S, Zhang YA*, Chen Z*.Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2.. .2016.59(11). . |
| 53. Da Y*, Wang W, Liu Z, Chen H, Di L, Previch L, Chen Z*.Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease.. .2016.38(10). . |
| 54. Tang X, Wang S, Bai Y, Wu J, Fu L, Li M, Xu Q, Xu ZQD, Zhang YA *, Chen Z *..Conversion of adult human peripheral blood mononuclear cells into neural stem cell by using episomal vectors.. .2016.16(2). . |
| 55. Xihe Tang a,b,c, Shuyan Wang a,b,c, Yunfei Bai d, Jianyu Wu a, Linlin Fu a, Mo Li a, Qunyuan Xub,Zhi-Qing David Xu d, Y. Alex Zhanga,c*,, Zhiguo Chen a,b,c,**.Conversion of adult human peripheral blood mononuclear cells into induced neural stem cell by using episomal vectors. .2016.16 (2016). . |
| 56. Li P#, Li M#, Tang X, Wang S, Zhang YA*, Chen Z*..Accelerated generation of oligodendrocyte progenitor cells from human induced pluripotent stem cells by forced expression of Sox10 and Olig2.. .2016.59(11). . |
| 57. Da Y*, Wang W, Liu Z, Chen H, Di L, Previch L, Chen Z*..Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease.. .2016.38(10). . |
| 58. 38. Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Izpisua Belmonte JC, Chen Z, Wang X, Jiang T, Qu J, Tang F, Liu GH*.PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.. .2015.6. . |
| 59. Chen Z*, Zhang YA*..Cell therapy for macular degeneration – first phase I/II pluripotent stem cell-based clinical trial shows promise.. .2015.58(1). . |
| 60. Chen Z*..Cell therapy for Parkinson’s disease: new hope from reprogramming technologies.. .2015.6(6). . |
| 61. Wang S, Zou C, Fu L, Wang B, An J, Song G, Wu J, Tang X, Li M, Zhang J, Yue F, Zheng C, Chan P, Zhang YA, Chen Z*..Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model.. .2015.2015（1）. . |
| 62. 2. Wang S, Wang B, Pan N, Fu L, Wang C, Song G, An J, Liu Z, Zhu W, Guan Y, Xu ZQD, Chan P, Chen Z*, Zhang YA.Differentiation of human induced pluripotent stem cells to functional Purkinje neurons.. .2015.5. . |
| 63. 36. Wang S, Zou C, Fu L, Wang B, An J, Song G, Wu J, Tang X, Li M, Zhang J, Yue F, Zheng C, Chan P, Zhang YA, Chen Z*.Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson’s disease model.. .2015.1. . |
| 64. Chen Z*, Zhang YA*.Cell therapy for macular degeneration – first phase I/II pluripotent stem cell-based clinical trial shows promise.. .2015.58(1). . |
| 65. Wang S, Wang B, Pan N, Fu L, Wang C, Song G, An J, Liu Z, Zhu W, Guan Y, Xu ZQD, Chan P, Chen Z*, Zhang YA..Differentiation of induced pluripotent stem cells to functional Purkinje neurons.. .2015.5. . |
| 66. Chen Z*, Zhang Y*.Introduction to the special topic "stem cells and regenerative medicine".. .2014.57(6). . |
| 67. Ren Z, Wang J, Wang S, Zou C, Li X, Guan Y, Chen Z *, Zhang YA *.Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys.. .2013.3. . |
| 68. Chen Z * and Palmer TD *.Differential roles of TNFR1 and TNFR2 signaling in adult hippocampal neurogenesis.. .2013.30. . |
| 69. Ren Z, Zhang YA*, Chen Z*.Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.. .2012.318(5). . |
| 70. Sheng C, Zheng Q, Wu J, Xu Z, Wang L, Li W, Zhang H, Zhao XY, Liu L, Wang Z, Guo C, Wu HJ, Liu Z, Wang L, He S, Wang XJ, Chen Z * and Zhou Q *.Direct Reprogramming of Sertoli Cells into Multipotent Neural Stem Cells by Defined Factors.. .2012.22(1). . |
| 71. Sheng C, Zheng Q, Wu J, Xu Z, Sang L, Wang L, Guo C, Zhu W, Tong M, Liu L, Zhao XY, Wang L, Chen Z * and Zhou Q *.Generation of dopaminergic neurons directly from mouse fibroblasts and fibroblast-derived neural progenitors.. .2012.22(4). . |
| 72. Ren Z, Zhang YA *, Chen Z *.Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysis.. .2012.318(5). . |
| 73. Chen Z *, Phillips LK, Gould E, Campisi J, Lee SW, Ormerod BK, Zwierzchoniewska M, Martinez O, Palmer TD *.MHC Mismatch Inhibits Neurogenesis and Neuron Maturation in Stem Cell Allografts.. .2011.6(3). . |
